Are Presenilins Intramembrane-Cleaving Proteases? Implications for the Molecular Mechanism of Alzheimer's Disease

S. Wolfe, Michael; De Los Angeles, Joseph; D. Miller, Duane; Xia, Weiming; J. Selkoe, Dennis

doi:10.1021/bi991080q

Public

Are Presenilins Intramembrane-Cleaving Proteases? Implications for the Molecular Mechanism of Alzheimer's Disease

Published in Biochemistry • Aug 1, 1999

Authors:

Michael S. Wolfe

Joseph De Los Angeles

Duane D. Miller

Abstract

The amyloid-beta protein (Abeta) is strongly implicated in the pathogenesis of Alzheimer's disease. The final step in the production of Abeta from the amyloid precursor protein (APP) is proteolysis by the unidentified gamma-secretases. This cleavage event is unusual in that it apparently occurs with...

Subject

Presenilin

Proteases

Amyloid precursor protein secretase

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