Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease.

MS, Wolfe; Los Angeles J, De; DD, Miller; W, Xia; DJ, Selkoe

doi:10.1021/bi991080q

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Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease.

Shared by NobleBlocks on Aug 1, 1999 • 12:00 AM UTC

Authors:

Wolfe MS

De Los Angeles J

Miller DD

Abstract

The amyloid-beta protein (Abeta) is strongly implicated in the pathogenesis of Alzheimer's disease. The final step in the production of Abeta from the amyloid precursor protein (APP) is proteolysis by the unidentified gamma-secretases. This cleavage event is unusual in that it apparently occurs with...

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