NF-κB mediates lipid-induced fetuin-A expression in hepatocytes that impairs adipocyte function effecting insulin resistance

Dasgupta, Suman; Bhattacharya, Sushmita; Biswas, Anindita; S. Majumdar, Subeer; Mukhopadhyay, Satinath; Ray, Sukanta; Bhattacharya, Samir

doi:10.1042/bj20100330

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NF-κB mediates lipid-induced fetuin-A expression in hepatocytes that impairs adipocyte function effecting insulin resistance

Published in Biochemical Journal • May 24, 2010

Authors:

Suman Dasgupta

Sushmita Bhattacharya

Anindita Biswas

Abstract

Fetuin-A, a hepatic secretory protein, has recently been implicated in insulin resistance and Type 2 diabetes. It is an endogenous inhibitor of insulin receptor tyrosine kinase. However, regulation of fetuin-A synthesis in relation to insulin resistance is unclear. In the present paper, we report th...

Subject

Insulin resistance

Internal medicine

Endocrinology

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