Mapping of DNA Instability at the Fragile X to a Trinucleotide Repeat Sequence P(CCG) <i>n</i>

J. Kremer, Eric; Pritchard, Melanie; Lynch, Michael; Yu, Shuancang; Holman, K.; Baker, Elizabeth; T. Warren, Stephen; Schlessinger, David; Sutherland, G.R.; I. Richards, Robert

doi:10.1126/science.1675488

Public

Mapping of DNA Instability at the Fragile X to a Trinucleotide Repeat Sequence P(CCG) n

Published in Science • Jun 21, 1991

Authors:

Eric J. Kremer

Melanie Pritchard

Michael Lynch

Abstract

The sequence of a Pst I restriction fragment was determined that demonstrate instability in fragile X syndrome pedigrees. The region of instability was localized to a trinucleotide repeat p(CCG)n. The sequence flanking this repeat were identical in normal and affected individuals. The breakpoints in...

Subject

Trinucleotide repeat expansion

Chromosomal fragile site

Genetics

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!