Age-related decreases in insulin-like growth factor-I and transforming growth factor-beta in femoral cortical bone from both men and women: implications for bone loss with aging.

Nicolas, Véronique; Prewett, A.; Bettica, P.; Mohan, Sneha; D. Finkelman, Richard; J. Baylink, David; R. Farley, John

doi:10.1210/jcem.78.5.8175953

Public

Age-related decreases in insulin-like growth factor-I and transforming growth factor-beta in femoral cortical bone from both men and women: implications for bone loss with aging.

Published in The Journal of Clinical Endocrinology & Metabolism • May 1, 1994

Authors:

Véronique Nicolas

A. Prewett

P. Bettica

Abstract

We determined the skeletal content of insulin-like growth factor-I (IGF-I) and transforming growth factor-beta (TGF beta) in human bone as a function of age, using 66 samples of femoral cortical bone obtained from 46 men and 20 women between the ages of 20-64 yr. We found a linear decline in the ske...

Subject

Endocrinology

Internal medicine

Insulin-like growth factor

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