Intravenous and Oral Itraconazole versus Intravenous Amphotericin B Deoxycholate as Empirical Antifungal Therapy for Persistent Fever in Neutropenic Patients with Cancer Who Are Receiving Broad-Spectrum Antibacterial Therapy

Boogaerts, Marc; J. Winston, Drew; J. Bow, Eric; Garber, Gary; C. Reboli, Annette; P. Schwarer, Anthony; Novitzky, Nicolas; Boehme, Angelika; Chwetzoff, Elisabeth; De Beule, Karel; the Itraconazole Neutropenia Study Group*, and

doi:10.7326/0003-4819-135-6-200109180-00010

Public

Intravenous and Oral Itraconazole versus Intravenous Amphotericin B Deoxycholate as Empirical Antifungal Therapy for Persistent Fever in Neutropenic Patients with Cancer Who Are Receiving Broad-Spectrum Antibacterial Therapy

Published in Annals of Internal Medicine • Sep 18, 2001

Authors:

Marc Boogaerts

Drew J. Winston

Eric J. Bow

Abstract

BACKGROUND: Amphotericin B deoxycholate is currently the standard empirical antifungal therapy in neutropenic patients with cancer who have persistent fever that does not respond to antibiotic therapy. However, this treatment often causes infusion-related and metabolic toxicities, which may be dose ...

Subject

Itraconazole

Amphotericin B

Medicine

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