<i>DICER1</i> Mutations in Familial Pleuropulmonary Blastoma

Ashley Hill, D.; Ivanovich, Jennifer; R. Priest, John; A. Gurnett, Christina; P. Dehner, Louis; M. Desruisseau, David; A. Jarzembowski, Jason; A. Wikenheiser‐Brokamp, Kathryn; K. Suarez, Brian; J. Whelan, Alison; M. Williams, Gretchen; Bracamontes, Dawn; H. Messinger, Yoav; J. Goodfellow, Paul

doi:10.1126/science.1174334

Public

DICER1 Mutations in Familial Pleuropulmonary Blastoma

Published in Science • Jun 26, 2009

Authors:

D. Ashley Hill

Jennifer Ivanovich

John R. Priest

Abstract

Pleuropulmonary blastoma (PPB) is a rare pediatric lung tumor that is often part of an inherited cancer syndrome. PPBs consist of mesenchymal cells that are susceptible to malignant transformation and cysts lined by epithelial cells. In a subset of patients, overgrowth of the cysts by mesenchymal ce...

Subject

Pulmonary Blastoma

Genetics

Mutation

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