Synthesis, Biochemical Properties and Molecular Modelling Studies of Organometallic Specific Estrogen Receptor Modulators (SERMs), the Ferrocifens and Hydroxyferrocifens: Evidence for an Antiproliferative Effect of Hydroxyferrocifens on both Hormone‐Dependent and Hormone‐Independent Breast Cancer Cell Lines

Top, Siden; Vessières, Anne; Leclercq, Guy; I. Quivy, Jacques; Tang, Jie; Vaissermann, Jacqueline; Huché, Michel; Jaouen, Gérard

doi:10.1002/chem.200305024

Public

Synthesis, Biochemical Properties and Molecular Modelling Studies of Organometallic Specific Estrogen Receptor Modulators (SERMs), the Ferrocifens and Hydroxyferrocifens: Evidence for an Antiproliferative Effect of Hydroxyferrocifens on both Hormone‐Dependent and Hormone‐Independent Breast Cancer Cell Lines

Published in Chemistry - A European Journal • Oct 10, 2003

Authors:

Siden Top

Anne Vessières

Guy Leclercq

Abstract

A series of ferrocene derivatives based upon the structure of the antiestrogenic drug tamoxifen or of its active metabolite hydroxytamoxifen has been prepared and named by analogy ferrocifens and hydroxyferrocifens. This series includes 1-[4-(O(CH(2))(n)NMe(2))phenyl]-1-phenyl-2-ferrocenyl-but-1-ene...

Subject

Chemistry

Stereochemistry

Tamoxifen

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