Interenzyme Substrate Diffusion for an Enzyme Cascade Organized on Spatially Addressable DNA Nanostructures

Fu, Jinglin; Liu, Minghui; Liu, Yan; W. Woodbury, Neal; Yan, Hao

doi:10.1021/ja300897h

Public

Interenzyme Substrate Diffusion for an Enzyme Cascade Organized on Spatially Addressable DNA Nanostructures

Published in Journal of the American Chemical Society • Mar 13, 2012

Authors:

Jinglin Fu

Minghui Liu

Yan Liu

Abstract

Spatially addressable DNA nanostructures facilitate the self-assembly of heterogeneous elements with precisely controlled patterns. Here we organized discrete glucose oxidase (GOx)/horseradish peroxidase (HRP) enzyme pairs on specific DNA origami tiles with controlled interenzyme spacing and positio...

Subject

Chemistry

Horseradish peroxidase

Diffusion

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