Small-Dose S(+)-Ketamine Reduces Postoperative Pain When Applied with Ropivacaine in Epidural Anesthesia for Total Knee Arthroplasty

Himmelseher, Sabine; Ziegler-Pithamitsis, Doris; Argiriadou, Helena; Martin, Jan; Jelen-Esselborn, S.; Kochs, E.

doi:10.1097/00000539-200105000-00040

Public

Small-Dose S(+)-Ketamine Reduces Postoperative Pain When Applied with Ropivacaine in Epidural Anesthesia for Total Knee Arthroplasty

Published in Anesthesia & Analgesia • May 1, 2001

Authors:

Sabine Himmelseher

Doris Ziegler-Pithamitsis

Helena Argiriadou

Abstract

UNLABELLED: Reduction of nociceptive input through blockade of N-methyl-D-aspartate (NMDA) receptors has been reported. We compared the effects of epidural S(+)-ketamine versus placebo on postoperative pain in a randomized, double-blinded study in 37 patients undergoing unilateral knee arthroplasty....

Subject

Ropivacaine

Medicine

Anesthesia

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