Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate

Rice, Ritva; Spencer‐Dene, Bradley; C. Connor, Elaine; Gritli-Linde, Amel; P. McMahon, Andrew; Dickson, Clive; Thesleff, Irma; Rice, David

doi:10.1172/jci20384

Public

Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate

Published in Journal of Clinical Investigation • Jun 15, 2004

Authors:

Ritva Rice

Bradley Spencer‐Dene

Elaine C. Connor

Abstract

Classical research has suggested that early palate formation develops via epithelial-mesenchymal interactions, and in this study we reveal which signals control this process.Using Fgf10 -/-, FGF receptor 2b -/- (Fgfr2b -/-), and Sonic hedgehog (Shh) mutant mice, which all exhibit cleft palate, we sh...

Subject

Mesenchyme

FGF10

Sonic hedgehog

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