Alkaline Phosphatase Knock-Out Mice Recapitulate the Metabolic and Skeletal Defects of Infantile Hypophosphatasia

N Fedde, K; A. Blair, Libby; Silverstein, Julie; P. Coburn, Stephen; M. Ryan, Lawrence; S. Weinstein, Robert; G. Waymire, Katrina; Narisawa, Sonoko; Luís Millán, José; R. MacGregor, Grant; P. Whyte, Michael

doi:10.1359/jbmr.1999.14.12.2015

Public

Alkaline Phosphatase Knock-Out Mice Recapitulate the Metabolic and Skeletal Defects of Infantile Hypophosphatasia

Published in Journal of Bone and Mineral Research • Dec 1, 1999

Authors:

K N Fedde

Libby A. Blair

Julie Silverstein

Abstract

Hypophosphatasia is an inborn error of metabolism characterized by deficient activity of the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP) and skeletal disease due to impaired mineralization of cartilage and bone matrix. We investigated two independently generated TNSALP gene knock-o...

Subject

Hypophosphatasia

Alkaline phosphatase

Endocrinology

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