Residual Arachidonic Acid–Induced Platelet Activation via an Adenosine Diphosphate–Dependent but Cyclooxygenase-1– and Cyclooxygenase-2–Independent Pathway

L. Frelinger, Andrew; I. Furman, Mark; D. Linden, Matthew; Li, Youfu; L. Fox, Marsha; R. Barnard, Marc; D. Michelson, Alan

doi:10.1161/circulationaha.105.596627

Public

Residual Arachidonic Acid–Induced Platelet Activation via an Adenosine Diphosphate–Dependent but Cyclooxygenase-1– and Cyclooxygenase-2–Independent Pathway

Published in Circulation • Jun 19, 2006

Authors:

Andrew L. Frelinger

Mark I. Furman

Matthew D. Linden

Abstract

BACKGROUND: Thrombotic events still occur in aspirin-treated patients with coronary artery disease. METHODS AND RESULTS: To better understand aspirin "resistance," serum thromboxane B2 (TXB2) and flow cytometric measures of arachidonic acid-induced platelet activation (before and after the ex vivo a...

Subject

Aspirin

Arachidonic acid

Medicine

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