A procedure is described for the large‐scale purification of light (L) and heavy (H) chain mRNAs from plasmacytomas produced in mice. Intact RNA is selectively precipitated in high yield from frozen tumors homogenized in 3 M LiCl and 6 M urea. L and H‐chain mRNAs were purified by oligo(dT)‐cellulose...
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