Influence of Environmental and Genetic Factors on CYP1A2 Activity in Individuals of South Asian and European Ancestry

Perera, Vidya; S. Gross, Annette; J. McLachlan, Andrew

doi:10.1038/clpt.2012.139

Public

Influence of Environmental and Genetic Factors on CYP1A2 Activity in Individuals of South Asian and European Ancestry

Published in Clinical Pharmacology & Therapeutics • Sep 5, 2012

Authors:

Vidya Perera

Annette S. Gross

Andrew J. McLachlan

Abstract

The drug-metabolizing enzyme CYP1A2 contributes to the metabolism of a number of commonly used medicines and displays wide interindividual variability. The aim of this study was to investigate CYP1A2 activity in a population of South Asian ancestry and compare it with a population of European ancest...

Subject

Paraxanthine

Caffeine

CYP1A2

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