Apoptosis Induction in HL-60 Cells and Inhibition of Topoisomerase II by Triterpene Celastrol

Nagase, Masahiro; OTO, Jinsei; SUGIYAMA, Sin; Yube, Kouichi; Takaishi, Yoshihisa; Sakato, Nobuo

doi:10.1271/bbb.67.1883

Public

Apoptosis Induction in HL-60 Cells and Inhibition of Topoisomerase II by Triterpene Celastrol

Published in Bioscience Biotechnology and Biochemistry • Jan 1, 2003

Authors:

Masahiro Nagase

Jinsei OTO

Sin SUGIYAMA

Abstract

Celastrol, which is a triterpene purified from Celastraceae plants, has anticancer and anti-inflammatory activities. In this study we investigated to clarify whether celastrol can induce apoptosis in a human leukemia HL-60 model system. Celastrol was found to induce apoptosis, and the rank order of ...

Subject

Celastrol

Triterpene

Topoisomerase

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