Dystrophins carrying spectrin-like repeats 16 and 17 anchor nNOS to the sarcolemma and enhance exercise performance in a mouse model of muscular dystrophy

Lai, Yi; D. Thomas, Gail; Yue, Yongping; T. Yang, H.; Li, Dejia; Long, Chun; M. Judge, Luke; Bostick, Brian; S. Chamberlain, Jeffrey; L. Terjung, Ronald; Duan, Dongsheng

doi:10.1172/jci36612

Public

Dystrophins carrying spectrin-like repeats 16 and 17 anchor nNOS to the sarcolemma and enhance exercise performance in a mouse model of muscular dystrophy

Published in Journal of Clinical Investigation • Feb 23, 2009

Authors:

Yi Lai

Gail D. Thomas

Yongping Yue

Abstract

Sarcolemma-associated neuronal NOS (nNOS) plays a critical role in normal muscle physiology. In Duchenne muscular dystrophy (DMD), the loss of sarcolemmal nNOS leads to functional ischemia and muscle damage; however, the mechanism of nNOS subcellular localization remains incompletely understood. Acc...

Subject

Sarcolemma

Dystrophin

Muscular dystrophy

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