Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c- MYC transcription

The nuclease hypersensitivity element III 1 upstream of the P1 promoter of c- MYC controls 85–90% of the transcriptional activation of this gene. We have demonstrated that the purine-rich strand of the DNA in this region can form two different intramolecular G-quadruplex structures, only one of whic... View More