Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c- <i>MYC</i> transcription

Siddiqui-Jain, Adam; L. Grand, Cory; J. Bearss, David; H. Hurley, Laurence

doi:10.1073/pnas.182256799

Public

Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c- MYC transcription

Published in Proceedings of the National Academy of Sciences • Aug 23, 2002

Authors:

Adam Siddiqui-Jain

Cory L. Grand

David J. Bearss

Abstract

The nuclease hypersensitivity element III(1) upstream of the P1 promoter of c-MYC controls 85-90% of the transcriptional activation of this gene. We have demonstrated that the purine-rich strand of the DNA in this region can form two different intramolecular G-quadruplex structures, only one of whic...

Subject

G-quadruplex

Repressor

Transcription (linguistics)

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