Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain

Cosenza-Nashat, Melissa; Zhao, Meng; Suh, H.‐S.; Morgan, Janet; Natividad, R.; Morgello, Susan; C. Lee, Sunhee

doi:10.1111/j.1365-2990.2008.01006.x

Public

Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain

Published in Neuropathology and Applied Neurobiology • Dec 11, 2008

Authors:

Melissa Cosenza-Nashat

Meng Zhao

H.‐S. Suh

Abstract

AIMS: Microglia are involved in neurodegeneration, are prime targets for anti-inflammatory therapy and are potential biomarkers of disease progression. For example, positron emission tomography imaging employing radioligands for the mitochondrial translocator protein of 18 kDa (TSPO, formerly known ...

Subject

Translocator protein

Microglia

Pathology

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