Hippocampal Myo-inositol and Cognitive Ability in Adults With Down Syndrome

Beacher, Felix; Simmons, Andy; Daly, Eileen; Prasher, Verinder; Adams, Claire; Luisa Margallo-Lana, Maria; G. Morris, Robin; Lovestone, Simon; C. Murphy, Kieran; Murphy, Declan

doi:10.1001/archpsyc.62.12.1360

Public

Hippocampal Myo-inositol and Cognitive Ability in Adults With Down Syndrome

Published in Archives of General Psychiatry • Dec 1, 2005

Authors:

Felix Beacher

Andy Simmons

Eileen Daly

Abstract

CONTEXT: Down syndrome (DS) is the most common genetic cause of mental retardation. However, the biological determinants of this are poorly understood. The serum sodium/myo-inositol cotransporter gene is located on chromosome 21, and myo-inositol affects neuronal survival and function. Nevertheless,...

Subject

Inositol

Hippocampal formation

Dementia

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