Extent of MGMT promoter methylation correlates with outcome in glioblastomas given temozolomide and radiotherapy

R Dunn, J; Baborie, Atik; Alam, F.; A Joyce, K; Moxham, M; Sibson, R.; Crooks, Daniel; Husband, David; Shenoy, Aditya; Brodbelt, Andrew; Wong, Helen; Liloglou, Triantafillos; Haylock, Brian; Walker, Carol

doi:10.1038/sj.bjc.6605127

Public

Extent of MGMT promoter methylation correlates with outcome in glioblastomas given temozolomide and radiotherapy

Published in British Journal of Cancer • Jun 16, 2009

Authors:

J R Dunn

Atik Baborie

F. Alam

Abstract

BACKGROUND: Epigenetic silencing of O(6)-methylguanine-DNA-methyltransferase (MGMT) by promoter methylation is associated with improved survival in glioblastomas treated with alkylating agents. In this study, we investigated MGMT promoter methylation in glioblastomas treated with temozolomide and ra...

Subject

Temozolomide

Methylation

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