Expression Cloning and Characterization of a Transporter for Large Neutral Amino Acids Activated by the Heavy Chain of 4F2 Antigen (CD98)

Kanai, Yoshikatsu; Segawa, Hiroko; Miyamoto, Ken‐ichi; Uchino, Hiroshi; Takeda, Eiji; Endou, Hitoshi

doi:10.1074/jbc.273.37.23629

Public

Expression Cloning and Characterization of a Transporter for Large Neutral Amino Acids Activated by the Heavy Chain of 4F2 Antigen (CD98)

Published in Journal of Biological Chemistry • Sep 1, 1998

Authors:

Yoshikatsu Kanai

Hiroko Segawa

Ken‐ichi Miyamoto

Abstract

A cDNA was isolated from rat C6 glioma cells by expression cloning which encodes a novel Na+-independent neutral amino acid transporter designated LAT1. For functional expression in Xenopus oocytes, LAT1 required the heavy chain of 4F2 cell surface antigen (CD98), a type II membrane glycoprotein. Wh...

Subject

Cloning (programming)

Antigen

Transporter

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!