Thirteen children with metastatic osteogenic sarcoma were given high-dose methotrexate (HDMTX) with Citrovorum factor (CF) rescue and adriamycin cyclic chemotherapy. HDMTX (100–750 mg/kg) IV. was infused during 4 hours, followed by CF administration (9 mg P.O. q6h × 12). Two weeks later, adriamycin,...