Randomized controlled trial of intraputamenal glial cell line–derived neurotrophic factor infusion in Parkinson disease

E. Lang, Anthony; Gill, Steven; K. Patel, Nik; Lozano, Andres; G. Nutt, John; Penn, Richard; J. Brooks, David; Hotton, Gary; Moro, Elena; Heywood, Peter; A. Brodsky, Matthew; Burchiel, Kim; Kelly, Patrick; Dalvi, Arif; Scott, Burton; Stacy, Mark; Turner, Dennis; G. Frederich Wooten, V.; J. Elias, William; R. Laws, Edward; Dhawan, Vijay; Jon Stoessl, A.; Matcham, James; J. Coffey, Robert; Traub, Michael

doi:10.1002/ana.20737

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Randomized controlled trial of intraputamenal glial cell line–derived neurotrophic factor infusion in Parkinson disease

Shared by NobleBlocks on Feb 17, 2006 • 12:00 AM UTC

Authors:

Anthony E. Lang

Steven Gill

Nik K. Patel

Abstract

Abstract Objective Glial cell line–derived neurotrophic factor (GDNF) exerts potent trophic influence on midbrain dopaminergic neurons. This randomized controlled clinical trial was designed to confirm initial clinical benefits observed in a small, open‐label trial using intraputamenal (Ipu) infusio...

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