Randomized controlled trial of intraputamenal glial cell line–derived neurotrophic factor infusion in Parkinson disease

E. Lang, Anthony; S. Gill, Steven; K. Patel, Nikunj; M. Lozano, Andrés; G. Nutt, John; D. Penn, Richard; J. Brooks, David; Hotton, Gary; Moro, Elena; Heywood, Peter; Brodsky, Matthew; J. Burchiel, Kim; J. Kelly, Patrick; Dalvi, Arif; Scott, B.L.; Stacy, Mark; A. Turner, Dennis; Wooten, Virginia; Jeff Elias, W.; R. Laws, Edward; Dhawan, Vijay; Jon Stoessl, A.; Matcham, James; J. Coffey, Robert; Traub, Michael

doi:10.1002/ana.20737

Public

Randomized controlled trial of intraputamenal glial cell line–derived neurotrophic factor infusion in Parkinson disease

Published in Annals of Neurology • Jan 20, 2006

Authors:

Anthony E. Lang

Steven S. Gill

Nikunj K. Patel

Abstract

OBJECTIVE: Glial cell line-derived neurotrophic factor (GDNF) exerts potent trophic influence on midbrain dopaminergic neurons. This randomized controlled clinical trial was designed to confirm initial clinical benefits observed in a small, open-label trial using intraputamenal (Ipu) infusion of rec...

Subject

Glial cell line-derived neurotrophic factor

Parkinson's disease

Dyskinesia

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