A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes

Moltke, Ida; Grarup, Niels; E. Jørgensen, Marit; Bjerregaard, Peter; T. Treebak, Jonas; Fumagalli, Matteo; Sand Korneliussen, Thorfinn; Andersen, Marianne; S. Nielsen, Thomas; T. Krarup, Nikolaj; P. Gjesing, Anette; R. Zierath, Juleen; Linneberg, Allan; Wu, Xueli; Sun, Guangqing; Jin, Xin; Y. Al‐Aama, Jumana; Wang, Jun; Borch‐Johnsen, Knut; Pedersen, Oluf; Nielsen, Rasmus; Albrechtsen, Anders; Hansen, Torben

doi:10.1038/nature13425

Public

A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes

Published in Nature • Jun 18, 2014

Authors:

Ida Moltke

Niels Grarup

Marit E. Jørgensen

Abstract

An association mapping study of type-2-diabetes-related quantitative traits in the Greenlandic population identified a common variant in TBC1D4 that increases plasma glucose levels and serum insulin levels after an oral glucose load and type 2 diabetes risk, with effect sizes several times larger th...

Subject

Internal medicine

Endocrinology

Type 2 diabetes

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!