Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region.

Moi, Paolo; Chan, Anthony; Asunis, Isadora; Cao, Antonio; Wai Kan, Yuet

doi:10.1073/pnas.91.21.9926

Public

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region.

Published in Proceedings of the National Academy of Sciences • Oct 11, 1994

Authors:

Paolo Moi

Anthony Chan

Isadora Asunis

Abstract

Hypersensitive site 2 located in the beta-globin locus control region confers high levels of expression to the genes of the beta-globin cluster. A tandem repeat of the consensus sequence for the transcription factors AP1 and NF-E2 (activating protein 1 and nuclear factor erythroid 2, respectively) i...

Subject

AP-1 transcription factor

Biology

Locus control region

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