Substrate Selectivity and a Novel Role in Inhibitor Discrimination by Residue 237 in the KPC-2 β-Lactamase

M. Papp‐Wallace, Krisztina; A. Taracila, Magdalena; M. Hornick, John; M. Hujer, Andrea; M. Hujer, Kristine; M. Distler, Anne; Endimiani, Andrea; A. Bonomo, Robert

doi:10.1128/aac.00197-10

Public

Substrate Selectivity and a Novel Role in Inhibitor Discrimination by Residue 237 in the KPC-2 β-Lactamase

Published in Antimicrobial Agents and Chemotherapy • Apr 27, 2010

Authors:

Krisztina M. Papp‐Wallace

Magdalena A. Taracila

John M. Hornick

Abstract

Beta-lactamase-mediated antibiotic resistance continues to challenge the contemporary treatment of serious bacterial infections. The KPC-2 beta-lactamase, a rapidly emerging gram-negative resistance determinant, hydrolyzes all commercially available beta-lactams, including carbapenems and beta-lacta...

Subject

Sulbactam

Cefotaxime

Beta-Lactamase Inhibitors

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