A metabolic switch toward lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis

Palamiuc, Lavinia; Schlagowski, A.; T. Ngo, Shyuan; Vernay, Aurélia; Dirrig‐Grosch, Sylvie; Henriques, Alexandre; Boutillier, Anne‐Laurence; Zoll, Joffrey; Echaniz‐Laguna, Andoni; Loeffler, Jean‐Philippe; René, Frédérique

doi:10.15252/emmm.201404433

Public

A metabolic switch toward lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis

Published in EMBO Molecular Medicine • Mar 27, 2015

Authors:

Lavinia Palamiuc

A. Schlagowski

Shyuan T. Ngo

Abstract

Amyotrophic lateral sclerosis (ALS) is the most common fatal motor neuron disease in adults. Numerous studies indicate that ALS is a systemic disease that affects whole body physiology and metabolic homeostasis. Using a mouse model of the disease (SOD1(G86R)), we investigated muscle physiology and m...

Subject

Amyotrophic lateral sclerosis

Glycolysis

SOD1

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