Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions

Alicia Salceda, Susana; Jaime, J.

doi:10.1074/jbc.272.36.22642

Public

Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions

Published in Journal of Biological Chemistry • Sep 1, 1997

Authors:

Susana Alicia Salceda

J. Jaime

Abstract

The hypoxia-inducible factor 1 transcriptional activator complex (HIF-1) is involved in the activation of the erythropoietin and several other hypoxia-responsive genes. The HIF-1 complex is composed of two protein subunits: HIF-1β/ARNT (aryl hydrocarbon receptor nuclear translocator), which is const...

Subject

Proteasome

Aryl hydrocarbon receptor nuclear translocator

Ubiquitin

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!