Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization

M. Orgogozo, J.; Gilman, S.; Dartigues, Jean‐François; Laurent, B.; Puel, Michèle; Kirby, L.; Jouanny, P.; Dubois, Bruno; S. Eisner, Larry; Flitman, Stephen; Michel, Bernard‐François; Boada, Merçé; Frank, Ana; Hock, C.

doi:10.1212/01.wnl.0000073623.84147.a8

Public

Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization

Published in Neurology • Jul 8, 2003

Authors:

J. M. Orgogozo

S. Gilman

Jean‐François Dartigues

Abstract

BACKGROUND: AD is characterized by cerebral deposition of beta-amyloid plaques with amyloid beta-peptide (Abeta) 42 as the major peptide constituent, along with neurofibrillary tangles and neuronal loss. In transgenic mice, active immunization against Abeta42 removes these plaques and improves cogni...

Subject

Tolerability

Medicine

Meningoencephalitis

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