Hypogonadotropic hypogonadism in mice lacking a functional <i>Kiss1</i> gene

d’Anglemont de Tassigny, Xavier; A. Fagg, Lisa; Dixon, John; Day, Kate; G. Leitch, Harry; G. Hendrick, Alan; Zahn, Dirk; Franceschini, Isabelle; Caraty, Alain; Carlton, Mark; Aparício, Samuel; H Colledge, William

doi:10.1073/pnas.0704114104

Public

Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene

Published in Proceedings of the National Academy of Sciences • Jun 12, 2007

Authors:

Xavier d’Anglemont de Tassigny

Lisa A. Fagg

John Dixon

Abstract

The G protein-coupled receptor GPR54 (AXOR12, OT7T175) is central to acquisition of reproductive competency in mammals. Peptide ligands (kisspeptins) for this receptor are encoded by the Kiss1 gene, and administration of exogenous kisspeptins stimulates hypothalamic gonadotropin-releasing hormone (G...

Subject

Kisspeptin

Internal medicine

Endocrinology

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