Tumor‐induced myeloid‐derived suppressor cell subsets exert either inhibitory or stimulatory effects on distinct <scp>CD</scp>8<sup>+</sup><scp>T</scp>‐cell activation events

Schouppe, Elio; Mommer, Camille; Movahedi, Kiavash; Laoui, Damya; Morias, Yannick; Gysemans, Conny; Luyckx, Ariane; De Baetselier, Patrick; A. Van Ginderachter, Jo

doi:10.1002/eji.201343349

Public

Tumor‐induced myeloid‐derived suppressor cell subsets exert either inhibitory or stimulatory effects on distinct CD8+T‐cell activation events

Published in European Journal of Immunology • Jul 23, 2013

Authors:

Elio Schouppe

Camille Mommer

Kiavash Movahedi

Abstract

Tumor growth coincides with an accumulation of myeloid-derived suppressor cells (MDSCs), which exert immune suppression and which consist of two main subpopulations, known as monocytic (MO) CD11b(+) CD115(+) Ly6G(-) Ly6C(high) MDSCs and granulocytic CD11b(+) CD115(-) Ly6G(+) Ly6C(int) polymorphonucl...

Subject

T cell

Myeloid-derived Suppressor Cell

Immune system

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