Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors.

G Nowak, Dawid; Woolard, Jeanette; Mohamed Amin, Elianna; Konopatskaya, Olga; A Saleem, Moin; J Churchill, Amanda; R Ladomery, Michael; J Harper, Steven; O Bates, David

doi:10.1242/jcs.016410

Public

Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors.

Published in Journal of cell science • Oct 15, 2008

NobleIDark:/48914/w1/20260526/28A3C5F4Record on NobleID

Authors:

Dawid G Nowak

,

Jeanette Woolard

,

Elianna Mohamed Amin

Abstract

Vascular endothelial growth factor A (VEGFA; hereafter referred to as VEGF) is a key regulator of physiological and pathological angiogenesis. Two families of VEGF isoforms are generated by alternate splice-site selection in the terminal exon. Proximal splice-site selection (PSS) in exon 8 results i...

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