Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors

G. Nowak, Dawid; Woolard, Jeanette; Amin, Elianna; Konopatskaya, Olga; A. Saleem, Moin; Churchill, A; Ladomery, Michael; J. Harper, Steven; O. Bates, David

doi:10.1242/jcs.016410

Public

Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors

Published in Journal of Cell Science • Oct 8, 2008

Authors:

Dawid G. Nowak

Jeanette Woolard

Elianna Amin

Abstract

Vascular endothelial growth factor A (VEGFA; hereafter referred to as VEGF) is a key regulator of physiological and pathological angiogenesis. Two families of VEGF isoforms are generated by alternate splice-site selection in the terminal exon. Proximal splice-site selection (PSS) in exon 8 results i...

Subject

Biology

Gene isoform

VEGF receptors

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