Denosumab in Men Receiving Androgen-Deprivation Therapy for Prostate Cancer

Smith, Matthew; Egerdie, Blair; Hernández Toriz, Narciso; Feldman, Robert; L.J. Tammela, Teuvo; Saad, Fred; Heráček, Jiří; Szwedowski, Maciej; Ke, Chunlei; Kupic, Amy; Z. Leder, Benjamin; Goessl, Carsten

doi:10.1056/nejmoa0809003

Public

Denosumab in Men Receiving Androgen-Deprivation Therapy for Prostate Cancer

Published in New England Journal of Medicine • Aug 11, 2009

Authors:

Matthew Smith

Blair Egerdie

Narciso Hernández Toriz

Abstract

BACKGROUND: Androgen-deprivation therapy is well-established for treating prostate cancer but is associated with bone loss and an increased risk of fracture. We investigated the effects of denosumab, a fully human monoclonal antibody against receptor activator of nuclear factor-kappaB ligand, on bon...

Subject

Medicine

Denosumab

Bone mineral

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