ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes

R. Parrilla Castellar, Edgardo; S. Jaffe, Elaine; Said, Jonathan; H. Swerdlow, Steven; P. Ketterling, Rhett; A. Knudson, Ryan; S. Sidhu, Jagmohan; D. Hsi, Eric; Karikehalli, Shridevi; Jiang, Liuyan; Vasmatzis, George; E. Gibson, Sarah; L. Ondrejka, Sarah; Nicolae, Alina; L. Grogg, Karen; Allmer, Cristine; M. Ristow, Kay; H. Wilson, Wyndham; R. Macon, William; E. Law, Mark; R. Cerhan, James; M. Habermann, Thomas; M. Ansell, Stephen; Doǧan, Ahmet; J. Maurer, Matthew; L. Feldman, Andrew

doi:10.1182/blood-2014-04-571091

Public

ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes

Published in Blood • Jun 3, 2014

Authors:

Edgardo R. Parrilla Castellar

Elaine S. Jaffe

Jonathan Said

Abstract

Anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma (ALCL) is a CD30-positive T-cell non-Hodgkin lymphoma that morphologically resembles ALK-positive ALCL but lacks chromosomal rearrangements of the ALK gene. The genetic and clinical heterogeneity of ALK-negative ALCL has not be...

Subject

Anaplastic large-cell lymphoma

Anaplastic lymphoma kinase

Lymphoma

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