The Major Brain Cholesterol Metabolite 24(S)-Hydroxycholesterol Is a Potent Allosteric Modulator of<i>N</i>-Methyl-d-Aspartate Receptors

M. Paul, Steven; Doherty, James; J. Robichaud, Albert; M. Belfort, Gabriel; Y. Chow, Brian; Hammond, Rebecca; C. Crawford, Devon; J. Linsenbardt, Andrew; Shu, Hong‐Jin; Izumi, Yukitoshi; Mennerick, Steven; F. Zorumski, Charles

doi:10.1523/jneurosci.2619-13.2013

Public

The Major Brain Cholesterol Metabolite 24(S)-Hydroxycholesterol Is a Potent Allosteric Modulator ofN-Methyl-d-Aspartate Receptors

Published in Journal of Neuroscience • Oct 30, 2013

Authors:

Steven M. Paul

James Doherty

Albert J. Robichaud

Abstract

N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels that are critical to the regulation of excitatory synaptic function in the CNS. NMDARs govern experience-dependent synaptic plasticity and have been implicated in the pathophysiology of various neuropsychiatric disorders includ...

Subject

NMDA receptor

Long-term potentiation

Allosteric modulator

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