Mutagenesis and Mapping of a Mouse Gene, Clock , Essential for Circadian Behavior

In a search for genes that regulate circadian rhythms in mammals, the progeny of mice treated with N -ethyl- N -nitrosourea (ENU) were screened for circadian clock mutations. A semidominant mutation, Clock , that lengthens circadian period and abolishes persistence of rhythmicity was identified. Clo... View More