Transforming Growth Factor-β Receptor Blockade Augments the Effectiveness of Adoptive T-Cell Therapy of Established Solid Cancers

F. Wallace, Africa; Kapoor, Veena; Sun, Jing; Mrass, Paul; Weninger, Wolfgang; F. Heitjan, Daniel; H. June, Carl; R. Kaiser, Larry; Ling, Leona; Μ. Albelda, Steven

doi:10.1158/1078-0432.ccr-08-0356

Public

Transforming Growth Factor-β Receptor Blockade Augments the Effectiveness of Adoptive T-Cell Therapy of Established Solid Cancers

Published in Clinical Cancer Research • Jun 15, 2008

Authors:

Africa F. Wallace

Veena Kapoor

Jing Sun

Abstract

PURPOSE: Adoptive cellular immunotherapy is a promising approach to eradicate established tumors. However, a significant hurdle in the success of cellular immunotherapy involves recently identified mechanisms of immune suppression on cytotoxic T cells at the effector phase. Transforming growth facto...

Subject

Adoptive cell transfer

Immunology

Immunotherapy

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