Inhibition of Xanthine Oxidase by Allopurinol Prevents Skeletal Muscle Atrophy: Role of p38 MAPKinase and E3 Ubiquitin Ligases

Derbré, Frederic; Ferrando, Beatriz; Carmen Gómez‐Cabrera, Mari; Sanchis‐Gomar, Fabián; E. Martínez-Bello, Vladimir; Olaso‐González, Gloria; Díaz, Ana; Gratas‐Delamarche, Arlette; Jover Cerdá, Miguel; Viña, José

doi:10.1371/journal.pone.0046668

Public

Inhibition of Xanthine Oxidase by Allopurinol Prevents Skeletal Muscle Atrophy: Role of p38 MAPKinase and E3 Ubiquitin Ligases

Published in PLoS ONE • Oct 5, 2012

Authors:

Frederic Derbré

Beatriz Ferrando

Mari Carmen Gómez‐Cabrera

Abstract

Alterations in muscle play an important role in common diseases and conditions. Reactive oxygen species (ROS) are generated during hindlimb unloading due, at least in part, to the activation of xanthine oxidase (XO). The major aim of this study was to determine the mechanism by which XO activation c...

Subject

Xanthine oxidase

Allopurinol

Muscle atrophy

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