Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

Colombo, Marina; Moita, Catarina; van Niel, Guillaume; Kowal, Joanna; Vigneron, J.; Benaroch, Philippe; Manel, Nicolas; F. Moita, Luís; Théry, Clotilde; Raposo, Graça

doi:10.1242/jcs.128868

Public

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

Published in Journal of Cell Science • Jan 1, 2013

Authors:

Marina Colombo

Catarina Moita

Guillaume van Niel

Abstract

Exosomes are extracellular vesicles (EVs) secreted upon fusion of endosomal multivesicular bodies (MVBs) with the plasma membrane. The mechanisms involved in their biogenesis have not yet been fully identified although they could be used to modulate exosome formation and therefore are a promising to...

Subject

ESCRT

Microvesicles

Biology

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