Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

Colombo, Marina; Moita, Catarina; van Niel, Guillaume; Kowal, Joanna; Vigneron, James; Benaroch, Philippe; Manel, Nicolas; F. Moita, Luis; Théry, Clotilde; Raposo, Graça

doi:10.1242/jcs.128868

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Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

Shared by NobleBlocks on Jan 1, 2013 • 12:00 AM UTC

Authors:

Marina Colombo

Catarina Moita

Guillaume van Niel

Abstract

Exosomes are extracellular vesicles (EVs) secreted upon fusion of endosomal multivesicular bodies (MVBs) with the plasma membrane. The mechanisms involved in their biogenesis remain so far unclear although they constitute targets to modulate exosome formation and therefore are a promising tool to un...

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