Increased Regulatory T Cells Correlate With CD8 T-Cell Impairment and Poor Survival in Hepatocellular Carcinoma Patients

Fu, Junliang; Xu, Dongping; Liu, Zhenwen; Shi, Ming; Zhao, Ping; Fu, Baoyun; Zhang, Zheng; Yang, Huiyin; Zhang, Hui; Zhou, Chun‐Bao; Yao, Jinxia; Jin, Lei; Wang, Huifen; Yang, Yongping; Fu, Yang-Xing; Wang, Fu‐Sheng

doi:10.1053/j.gastro.2007.03.102

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Increased Regulatory T Cells Correlate With CD8 T-Cell Impairment and Poor Survival in Hepatocellular Carcinoma Patients

Published in Gastroenterology • Apr 15, 2007

Authors:

Junliang Fu

Dongping Xu

Zhenwen Liu

Abstract

BACKGROUND & AIMS: Recent studies have suggested that CD4(+)CD25(+) regulatory T cells (Treg) are increased and linked to compromised immune responses in patients with hepatocellular carcinoma (HCC). This study attempted to further characterize CD4(+)CD25(+) forkhead/winged helix transcription facto...

Subject

FOXP3

Granzyme B

Hepatocellular carcinoma

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