Clinical and biological implications of driver mutations in myelodysplastic syndromes

Papaemmanuil, Elli; Gerstung, Moritz; Malcovati, Luca; Tauro, Sudhir; Gundem, Gunes; Van Loo, Peter; Yoon, Sung-Soo; Ellis, Peter; C. Wedge, David; Pellagatti, Andrea; Shlien, Adam; J. Groves, Michael; Forbes, Simon; Raine, Keiran; Hinton, Jon; Mudie, Laura; McLaren, Stuart; Hardy, Claire; Latimer, Calli; Giovanni Della Porta, Matteo; O’Meara, Sarah; Ambaglio, Ilaria; Gallì, Anna; P. Butler, Adam; Walldin, Gunilla; W. Teague, Jon; Quek, Lynn; Sternberg, Alex; Gambacorti‐Passerini, Carlo; C.P. Cross, Nicholas; R. Green, Anthony; Boultwood, Jacqueline; Vyas, Paresh; Hellström‐Lindberg, Eva; Bowen, David; Cazzola, Mario; R. Stratton, Michael; J. Campbell, Peter

doi:10.1182/blood-2013-08-518886

Public

Clinical and biological implications of driver mutations in myelodysplastic syndromes

Published in Blood • Sep 13, 2013

Authors:

Elli Papaemmanuil

Moritz Gerstung

Luca Malcovati

Abstract

Myelodysplastic syndromes (MDS) are a heterogeneous group of chronic hematological malignancies characterized by dysplasia, ineffective hematopoiesis and a variable risk of progression to acute myeloid leukemia. Sequencing of MDS genomes has identified mutations in genes implicated in RNA splicing, ...

Subject

Myelodysplastic syndromes

Gene

Genetics

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