Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia.

XS, Puente; M, Pinyol; V, Quesada; L, Conde; GR, Ordóñez; N, Villamor; G, Escaramis; P, Jares; S, Beà; M, González-Díaz; L, Bassaganyas; T, Baumann; M, Juan; M, López-Guerra; D, Colomer; JM, Tubío; C, López; A, Navarro; C, Tornador; M, Aymerich; M, Rozman; JM, Hernández; DA, Puente; JM, Freije; G, Velasco; A, Gutiérrez-Fernández; D, Costa; A, Carrió; S, Guijarro; A, Enjuanes; L, Hernández; J, Yagüe; P, Nicolás; CM, Romeo-Casabona; H, Himmelbauer; E, Castillo; JC, Dohm; Sanjosé S, de; MA, Piris; Alava E, de; Miguel J, San; R, Royo; JL, Gelpí; D, Torrents; M, Orozco; DG, Pisano; A, Valencia; R, Guigó; M, Bayés; S, Heath; M, Gut; P, Klatt; J, Marshall; K, Raine; LA, Stebbings; PA, Futreal; MR, Stratton; PJ, Campbell; I, Gut; A, López-Guillermo; X, Estivill; E, Montserrat; C, López-Otín; E, Campo

doi:10.1038/nature10113

Public

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia.

Shared by NobleBlocks on Jun 5, 2011 • 12:00 AM UTC

Authors:

Puente XS

Pinyol M

Quesada V

Abstract

Chronic lymphocytic leukaemia (CLL), the most frequent leukaemia in adults in Western countries, is a heterogeneous disease with variable clinical presentation and evolution. Two major molecular subtypes can be distinguished, characterized respectively by a high or low number of somatic hypermutatio...

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