Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock*

Kumar, Anand; Roberts, Daniel; E. Wood, Kenneth; Light, Bruce; E. Parrillo, Joseph; Sharma, Satendra; Suppes, Robert; Feinstein, Daniel; Zanotti, Sergio; Taiberg, Leo; P. Gurka, David; Kumar, Aseem; Cheang, Mary

doi:10.1097/01.ccm.0000217961.75225.e9

Public

Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock*

Published in Critical Care Medicine • Apr 19, 2006

Authors:

Anand Kumar

Daniel Roberts

Kenneth E. Wood

Abstract

OBJECTIVE: To determine the prevalence and impact on mortality of delays in initiation of effective antimicrobial therapy from initial onset of recurrent/persistent hypotension of septic shock. DESIGN: A retrospective cohort study performed between July 1989 and June 2004. SETTING: Fourteen intensiv...

Subject

Medicine

Septic shock

Odds ratio

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