Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD

González‐Rodríguez, Águeda; Mayoral, Rafael; Vázquez-Agra, Néstor; Pilar Valdecantos, M.; Pardo, Virginia; E. Miquilena-Colina, María; Vargas‐Castrillón, Javier; Lo Iacono, Oreste; Corazzari, Marco; María Fimia, Gian; Piacentini, Mauro; Muntané, Jordi; Boscá, Lisardo; García‐Monzón, Carmelo; Martín‐Sanz, Paloma; M. Valverde, Ángela

doi:10.1038/cddis.2014.162

Public

Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD

Published in Cell Death and Disease • Apr 17, 2014

Authors:

Águeda González‐Rodríguez

Rafael Mayoral

Néstor Vázquez-Agra

Abstract

The pathogenic mechanisms underlying the progression of non-alcoholic fatty liver disease (NAFLD) are not fully understood. In this study, we aimed to assess the relationship between endoplasmic reticulum (ER) stress and autophagy in human and mouse hepatocytes during NAFLD. ER stress and autophagy ...

Subject

Unfolded protein response

Endoplasmic reticulum

Autophagy

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