β-Arrestin-dependent, G Protein-independent ERK1/2 Activation by the β2 Adrenergic Receptor

K. Shenoy, Sudha; T. Drake, Matthew; Nelson, Christopher; A. Houtz, Daniel; Xiao, Kunhong; Madabushi, Srinivasan; Reiter, Éric; T. Premont, Richard; Lichtarge, Olivier; J. Lefkowitz, Robert

doi:10.1074/jbc.m506576200

Public

β-Arrestin-dependent, G Protein-independent ERK1/2 Activation by the β2 Adrenergic Receptor

Published in Journal of Biological Chemistry • Nov 9, 2005

Authors:

Sudha K. Shenoy

Matthew T. Drake

Christopher Nelson

Abstract

Physiological effects of beta adrenergic receptor (beta2AR) stimulation have been classically shown to result from G(s)-dependent adenylyl cyclase activation. Here we demonstrate a novel signaling mechanism wherein beta-arrestins mediate beta2AR signaling to extracellular-signal regulated kinases 1/...

Subject

Pertussis toxin

Arrestin

G protein

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