Long-term efficacy and safety of <i>all-trans</i> retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia

Hu, Jiong; Liu, Yuan-Fang; Wu, Chuan-Feng; Xu, Fang; Shen, Zhi-Xiang; Zhu, Yong-Mei; Li, Junmin; Tang, Wei; Zhao, Weili; Wu, Wen; Sun, Hui-Ping; Chen, Qiu-Sheng; Chen, Bing; Zhou, Guang‐Biao; Zelent, Arthur; Waxman, Samuel; Wang, Zhen-Yi; Chen, Sai-Juan; Chen, Zhu

doi:10.1073/pnas.0813280106

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Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia

Published in Proceedings of the National Academy of Sciences • Feb 18, 2009

Authors:

Jiong Hu

Yuan-Fang Liu

Chuan-Feng Wu

Abstract

All-trans retinoic acid (ATRA)/arsenic trioxide (ATO) combination-based therapy has benefitted newly diagnosed acute promyelocytic leukemia (APL) in short-term studies, but the long-term efficacy and safety remained unclear. From April 2001, we have followed 85 patients administrated ATRA/ATO with a...

Subject

Arsenic trioxide

Acute promyelocytic leukemia

Medicine

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