A genomic polymorphism within the tumor necrosis factor locus influences plasma tumor necrosis factor-alpha concentrations and outcome of patients with severe sepsis

Stüber, Frank; Petersen, Marc; Bokelmann, Frank; F. Schade, Ulrich

doi:10.1097/00003246-199603000-00004

Public

A genomic polymorphism within the tumor necrosis factor locus influences plasma tumor necrosis factor-alpha concentrations and outcome of patients with severe sepsis

Published in Critical Care Medicine • Mar 1, 1996

Authors:

Frank Stüber

Marc Petersen

Frank Bokelmann

Abstract

OBJECTIVES: To determine the allele frequency and genotype distribution of a bi-allelic tumor necrosis factor (TNF) gene polymorphism and plasma TNF-alpha concentrations in postoperative intensive care unit (ICU) patients suffering from severe sepsis. DESIGN: Prospective, consecutive entry study of ...

Subject

Tumor necrosis factor alpha

Medicine

Sepsis

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