Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA

S. Diebold, Sandra; Kaisho, Tsuneyasu; Hemmi, Hiroaki; Akira, Shizuo; Reis e Sousa, Caetano

doi:10.1126/science.1093616

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Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA

Shared by NobleBlocks on Mar 5, 2004 • 12:00 AM UTC

Authors:

Sandra S. Diebold

Tsuneyasu Kaisho

Hiroaki Hemmi

Abstract

Interferons (IFNs) are critical for protection from viral infection, but the pathways linking virus recognition to IFN induction remain poorly understood. Plasmacytoid dendritic cells produce vast amounts of IFN-α in response to the wild-type influenza virus. Here, we show that this requires endosom...

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