A case—control study of apolipoprotein E genotypes in Alzheimer's disease associated with Down's syndrome

A. van Gool, Willem; M. Evenhuis, Heleen; M. van Duijn, Cornelia; of the Dutch Study Group on Down's Syndrome and Ageing, Behalf

doi:10.1002/ana.410380215

Public

A case—control study of apolipoprotein E genotypes in Alzheimer's disease associated with Down's syndrome

Published in Annals of Neurology • Aug 1, 1995

Authors:

Willem A. van Gool

Heleen M. Evenhuis

Cornelia M. van Duijn

Abstract

The prevalence of clinical signs and neuropathological findings of Alzheimer's disease (AD) is high in Down's syndrome (DS). In the general population, the apolipoprotein E (ApoE) epsilon 4 isoform is an important risk for AD. We studied the allelic frequencies of ApoE in 26 DS cases fulfilling clin...

Subject

Apolipoprotein E

Allele

Alzheimer's disease

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