Origin of myofibroblasts in the fibrotic liver in mice

Iwaisako, Keiko; Jiang, Chunyan; Zhang, Mingjun; Cong, Min; Moore‐Morris, Thomas; Jun Park, Tae; Liu, Xiao; Xu, Jun; Wang, Ping; Paik, Yong‐Han; Meng, Fanli; Asagiri, Masataka; A. Murray, Lynne; F. Hofmann, Alan; Iida, Takashi; K. Glass, Christopher; A. Brenner, David; Kisseleva, Tatiana

doi:10.1073/pnas.1400062111

Public

Origin of myofibroblasts in the fibrotic liver in mice

Published in Proceedings of the National Academy of Sciences • Jul 29, 2014

Authors:

Keiko Iwaisako

Chunyan Jiang

Mingjun Zhang

Abstract

Hepatic myofibroblasts are activated in response to chronic liver injury of any etiology to produce a fibrous scar. Despite extensive studies, the origin of myofibroblasts in different types of fibrotic liver diseases is unresolved. To identify distinct populations of myofibroblasts and quantify the...

Subject

Hepatic stellate cell

Myofibroblast

Liver injury

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